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Genetic examination in IVF treatment

The most important step in the treatment of infertility is to choose the embryo that will give the chance of pregnancy. The most important topic of discussion of reproductive medicine is which criteria to choose the right embryo according to. Today, the criteria scored using time-lapse systems are used with the rating according to the morphological image under the microscope.

Theoretically, genetically healthy embryos are the most likely embryos for pregnancy and healthy birth. The current selection criteria cannot foresee whether the embryo is genetically healthy.

Even if there are no genetic abnormalities in couples, it is revealed in studies that embryos are 40-60 percent genetically abnormal, and this rate increases as the expectant mother ages.

In order to perform PGS, a biopsy of the embryo is required and a trophoectomy biopsy is preferred from the embryo of 5.g. The two most common methods used in PGS are the next generation sequence (NGS) with cgh array. CGH Array will need to freeze embryos in NGS while giving you the chance to transfer fresh. Despite this disadvantage, the results are more reliable in NGS.

Clinically used conditions today are advanced maternal age, recurrent IVF failures, recurrent early pregnancy losses and the need for single embryo transfer.

Although knowing that embryos are genetically healthy is the most important point in embryo selection, studies show that genetically normal embryo transfer with PGS does not increase pregnancy rates and the chances of implantation success.

When recommending the PGS method to our patients, we decide by explaining their advantages and disadvantages very well.

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